Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles

L-Asparaginase (ASNase) is a vital component of the first line treatment of acute lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over 53,000 people worldwide by 2020.More recently, ASNase has also been shown to have potential for preventing metastasis from solid tumors.The ASNase treatment is, however, characte

read more


Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

Abstract Background Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community.However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges.Hypothetically, cancer cell membrane (CCM) can homolog

read more